Cannapedia Encyclopedia of cannabis strains

Endocannabinoid System

The endocannabinoid system is a central signal receptor system affecting variety of biological processes. It consists of a group of molecules known as endocannabinoids and of cannabinoid receptors that these molecules bind to.

Major endogenous cannabinoids (endocannabinoids) produced by a human body, which we have discovered so far, are anandamide and 2-arachidonoylglycerol (2-AG). Besides endocannabinoids, there exist also phytocannabinoids (commonly known as cannabinoids) that are found almost exclusively in the cannabis plant and also bind to the cannabinoid receptors in our body.

Long-time scientific research of the endocannabinoid system led to a discovery of two types of cannabinoid receptors – CB1 and CB2. These receptors are located in different body parts, but mostly in the brain (CB1) and in the immune system (CB2).

Both endocannabinoids and phytocannabinoids fit into these receptors like a key in the lock. Binding of endocannabinoids or phytocannabinoids to CB1 and CB2 receptors affects physiological processes within our bodies and explains a wide range of therapeutic properties of cannabis.

Scientists are gradually discovering these receptors in various places (besides the brain and the immune system), including circulatory, reproductive, digestive or urinary system. All these discoveries support the claim that the endocannabinoid system – although discovered relatively recently – is absolutely crucial for the correct functioning of the body. It has always been and it always will be. 

Endokanabinoidní systém