Cannapedia Encyclopedia of cannabis strains

Entourage Effect

There is still a lot left to discover and understand about cannabis. However, the current knowledge already includes a notion that the health effects of cannabis are based on many chemical compounds (terpenes, cannabinoids, etc.) acting together.

Amongst cannabis researchers, this phenomenon is known as synergy or an ‘entourage effect’.



The notion of a synergistic effect is becoming increasingly important in cannabis world. It describes the relation between terpenes, cannabinoids and other compounds produced by this plant, which are responsible for wide and diverse medical potential of cannabis.

Cannabinoids, such as THC and CBD, are already thoroughly described and analyzed. These compounds have a whole range of healing effects; they, however, are only a part of the reason for such a high medical effectivity of cannabis. For example, it was repeatedly proven that administered alone, they are less effective than combined or in addition to various terpenes.

Both cannabinoids and terpenes react with receptors in the endocannabinoid system, improving the overall therapeutic effect of cannabis on human body.


Hidden treasure called terpenes

According to latest science, it is terpenes, not cannabinoids, what modulates (adjust or control) the effects of various strains. This is also why every strain’s effects are different. In two strains which both have 15% of THC with one acting as a stimulant while the other makes you fall asleep, the difference is due to the varying terpene content. For example, terpenes such as myrcene, neroditol and terpinolene act as sedatives, while alpha-pinene acts as stimulant. While cannabinoids and terpenes can work in isolation and independently, it is only after they are combined (act synergistically), that they provide the most effective treatment for diseases.